83P Axillary reverse mapping using near-infrared fluorescence imaging in invasive breast cancer (ARMONIC study)

Axillary Reverse Mapping in Breast Cancer

Axillary lymph node dissection represents the standard surgical treatment for breast cancer patients with clinically or histologically involved axillary lymph nodes. However, it is associated with significant morbidity, including postoperative arm lymphedema and neuropathy of the involved extremity, and seroma formation in the axilla (Noguchi et al., 1997). Particularly, arm lymphedema develops...

Non-Invasive In Vivo Imaging of Near Infrared-labeled Transferrin in Breast Cancer Cells and Tumors Using Fluorescence Lifetime FRET

The conjugation of anti-cancer drugs to endogenous ligands has proven to be an effective strategy to enhance their pharmacological selectivity and delivery towards neoplasic tissues. Since cell proliferation has a strong requirement for iron, cancer cells express high levels of transferrin receptors (TfnR), making its ligand, transferrin (Tfn), of great interest as a delivery agent for therapeu...

Axillary reverse mapping in breast cancer with enlarged lymph node

Objective: The research is to explore the success rate and safety of axillary reverse mapping (ARM) and the effect on the function and lymphedema of ipsilateral upper limb, and to investigate the quality-of-life of patients with breast cancer after operation, as well as to explore the related factors affecting the success rate of ARM. Methods: In operation of 60 cases of female patients with en...

Improving 3-D Imaging Breast Cancer Diagnosis Systems Using a New Method for Placement of Near-Infrared Sources and Detectors

The objective of this research was to improve 3-D imaging system by near-infrared light emission in breast tissue to achieve a more accurate diagnosis of tumor. The results of repeated experiments in this research have shown that with this imaging system, a more accurate diagnosis of abnormal area depends on the location of the sources and detectors. Therefore, an optimal location model has bee...

Evaluation of Reflection Optical Imaging Characteristics Using Fluorescence with Near Infrared Wavelength at Different Depths of Tissue Equivalent Phantom